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《高分子科学(英文版)》 2018-10
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Bioinspired Water-soluble Polymers with Grafted Polyamine Chains:Synthesis and Complexation with Oligonucleotides

Vadim V.Annenkov;Uma Maheswari Krishnan;Viktor A.Pal'shin;Stanislav N.Zelinskiy;Gayathri Kandasamy;Elena N.Danilovtseva;Limnological Institute of the Siberian Branch of the Russian Academy of Sciences;Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical and Biotechnology, SASTRA University;  
The siliceous frustules of diatom algae contain complex proteins known as silaffins, which consist of a peptide chain with grafted polyamine chains. These polyamines contain twenty or more nitrogen atoms with trimethylene groups between the nitrogens. We synthesized a set of polymers containing grafted long-chain polyamine fragments by using acryloyl chloride(ACh) polymers and activated acrylic acid copolymers as the starting materials. The new polymers contained 0.05 mol%-3.2 mol% of polyamine chains, which corresponded to 0.06-3.56 mmol·g~(-1) amine groups. The new amine-containing polymers formed complexes with short(19-21-mer)deoxyribonucleic acid(DNA) and ribonucleic acid(RNA) strands, and these complexes penetrated into model yeast cells and A549 lung cancer cell. This study demonstrates the potential of these species based on long-chain polyamines to serve as novel gene delivery systems.
【Fund】: financial support from a joint grant of the Russian Science Foundation(#6-45-02001);; the Department of Science Technology of the Ministry of Science and Technology of the Republic of India(#INT/RUS/RSF/10)
【CateGory Index】: O631
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