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《Chinese Journal of Bone and Joint Injury》 2011-12
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Low Frequency Vibration Stimulation and BMSCs to Repair Bone Defect in Vivo Experiment

Du Guangyu,Zhao Wenzhi,He Shengwei,et al.Department of Orthopaedics,the Second Affiliated Hospital of Dalian Medical University,Dalian,116031  
Objective To study the feasibility of bone marrow stromal cells as seed cells grown in the demineralized bone matrix combined with the low-frequency vibration to repair cranial bone defects.Methods All of 30 rabbits were divided into 3 groups randomly.A group: transplantation demineralized bone matrix.B,C group: transplantation demineralized bone matrix and BMSCs.A and B group were vibrated by 25 HZ.C group was not vibrated.Results The healing in the bone defect in B group was significantly better than A and C group(P 0.05),observed by the gross specimen,histology,electron microscopy and biochemical analysis of test results.Conclusion The bone marrow stromal cells as seed cells grown in the demineralized bone matrix combined with the low-frequency vibration can promote the repair of bone defects.
【Fund】: 国家自然科学基金资助项目(30970708)
【CateGory Index】: R318.08;R687.3
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