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《国际感染杂志(电子版)(英文版)》 2012-01
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The Role of Autophagy in Hepatitis C Virus Infection

Jun Cheng;Min Quan;Liang Wu;Qi Wang;  
Hepatitis C virus(HCV) infects ≈2%of the world's population.HCV infection not only causes acute and chronic hepatitis,but also leads to liver cirrhosis and hepatocellular carcinoma(HCC).The molecular pathogenesis of HCV infection has been explored and many evidence indicated that autophagy is an important process for its life cycle,although autophagy was thought as a mechanism to eliminate invaded HCV from hepatocyte.Structural and non-structural proteins of HCV are important regulators of autophagy,and HCV uses autophagy as a necessary step in its replication.Down-regulation of innate immune response by HCV through unfolded protein response(UPR) and autophagy induction was used as a pathway to establish chronic HCV infection in the liver.Meanwhile,the infected hepatocyte is also using autophagy mechanism to eradicate HCV virus from liver.The study on relationship between HCV and autophagy will pave the new way to understand HCV life cycle and to find new strategy for prevention and treatment of liver diseases caused by HCV infection.
【CateGory Index】: R512.63
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HOU Li-ying;SUN Yan-pei;ZHANG Xu-guang;ZHAO Dong;WU Kun;Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University;Department of Cardiac Surgery,Harbin Children's Hospital;;Vitamin E succinate induced protective autophagy in human gastric cancer cells SGC-7901 via the Akt/mTOR signaling pathway[J];Carcinogenesis,Teratogenesis & Mutagenesis;2013-05
2 ZHONG WenYing;Lü Min;LIU LiYing;SUN JinLi;ZHONG ZengTao;ZHAO Yun;SONG HaiYun;School of Life Science,Sichuan University;Institute for Nutritional Sciences,Shanghai Institutes for Biological Sciences;College of Life Sciences,Nanjing Agricultural University;;Autophagy as new emerging cellular effect of nanomaterials[J];科学通报(英文版);2013-33
3 FANG Li;WANG Xuejing;JING Jing;MA Yaohua;DENG Wenjing;ZHANG Wenwen;TENG Junfang;Department of Neurology,the First Affiliated Hospital,Zhengzhou University;Henan Key Laboratory for Clinical Medicine,the First Affiliated Hospital,Zhengzhou University;;Effects of rhG-CSF on macroautophagy of ischemia hypoxia SH-SY5Y cells and rat neurons[J];Journal of Zhengzhou University(Medical Sciences);2013-06
4 Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States;Role of autophagy in liver physiology and pathophysiology[J];世界生物化学杂志(电子版)(英文版);2010-01
5 LI Ling;XU Xiao-Jie;YE Qi-Nong;Beijing Institute of Biotechnology;;Autophagy and Tumor[J];Chinese Journal of Biochemistry and Molecular Biology;2013-11
6 REN Lin-lin,FANG Jing-yuan(Gastro intestinal Division,Renji Hospital,School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Diseases,Shanghai 200001,China);Progress of epigenetic study on autophagy in tumor[J];China Oncology;2011-06
7 CHEN Liang;SUN Yi-fan;CHEN Tao;LI Hai-cheng;JIANG Zhen-you;ZHOU Lin;ZHONG Qiu;Guangdong Center for Tuberculosis Control;;Optimization of culture for THP-1 derived macrophages induced by PMA and establishment of autophagy model[J];Chinese Journal of Antituberculosis;2013-12
8 LIN Ye;WANG Fang;Department of Cardiology,the First People's Hospital Affiliated to Shanghai Jiaotong University;;The mechanism and Function of Sirt1 in Myocardial Diseases[J];Molecular Cardiology of China;2013-06
9 HOU Yi-ju;CHANG Qing;GUO Wei;YUAN Zhong-hai;LI Yan;Department of Hematology Inspection,Jinlin Medical College;Department of Gastroenterology,General Hospital of the Chinese People's Liberation Army;Cancer Treatment Center,First Clinical Hospital of Jilin University;;Inhibition of Rapamycin on Proliferation of Human Acute Promyelocytic Leukemia HL60 Cells[J];Chinese Pharmaceutical Journal;2013-23
10 Vitalba Ruggieri;Carmela Mazzoccoli;Valerio Pazienza;Angelo Andriulli;Nazzareno Capitanio;Claudia Piccoli;Laboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture (PZ), Italy;Gastroenterology Unit,IRCCS, "Casa Sollievo della Sofferenza" Hospital, 71013 Foggia, Italy;Department of Medical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy;;Hepatitis C virus,mitochondria and auto/mitophagy:Exploiting a host defense mechanism[J];世界胃肠病学杂志(英文版);2014-10
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