Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《International Eye Science》 2019-04
Add to Favorite Get Latest Update

Vascular endothelial growth factor and chemokine receptor-3 in the pathogenesis of pterygium

Hui Liu;Min Zhang;Department of Ophthalmology,Xiangyang First People's Hospital Affiliated to Hubei Medical University;  
AIM: To investigate the expression of vascular endothelial growth factor( VEGF) and chem okine receptor3( CCR3) in pterygium.METHODS: The expression of VEGF and CCR3 were detected in 18 patients( 18 eyes) with pterygium and com pared with the norm al conjunctiva epithelium in other14 cases( 14 eyes). The histological differences between the tw o groups were com pared by hem atoxylin and eosin( HE) staining. The expression of VEGF and CCR3 in pterygium and norm al conjunctival tissues were analyzed by im m unofluorescence and im m unohistochem ical. The m RNA expression of VEGF and CCR3 were assessed by Real-tim e PCR.RESULTS: Compared with normal conjunctival tissue,the epithelial layer of pterygium was obvious thickening,the strom al layer was m ore disordered, and the expression levels of VEGF( 0. 69 ± 0. 0875 vs 0. 05 ± 0. 0024)and CCR3( 0.45±0.0248 vs 0.03±0.0074) were significantly elevated( all P 0. 01). The expression level of VEGF m RNA in pterygium was about 12 tim es that of norm al conjunctival tissue( 12. 33 ± 2. 84 vs 1. 00 ± 0. 08),and the expression level of CCR3 m RNA was about 160 tim es as m any as conjunctival tissue( 159.60±34.15 vs 1.00±0.09).CONCLUSION: The expression of VEGF and CCR3 in pterygium was significantly increased, suggesting that they m ay be involved in the occurrence of pterygium and prom ote the developm ent of the disease.
【Fund】: 襄阳市科技局市级科技计划项目(No.2015zd11)~~
【CateGory Index】: R779.6
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 5 Hits
1 Xian-Wei Wu;Zhe-Li Liu;Department of Ophthalmology,Benxi Central Hospital;Department of Ophthalmology,the First Hospital of China Medical University;;Study progress of CCR3 in wet age-related macular degeneration[J];国际眼科杂志;2014-03
2 Wen-Juan Zhou 1,Gao-Qin Liu 1,2,Long-Biao Li 1,Xue-Guang Zhang 2,Pei-Rong Lu 1,2 1 Department of Ophthalmology,the First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu Province,China 2 Jiangsu Institute of Clinic Immunology,the First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu Province,China;Inhibitory effect of CCR3 signal on alkali-induced corneal neovascularization[J];International Journal of Ophthalmology(English Edition);2012-03
3 Jie ZHANG,Mingchang ZHANG #,Xiaoqing LI,Tian ZHENG,Ge MU,Wei LIU,Huatao XIE,Xin LIU Department of Ophthalmology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Correlation of Vascular Endothelial Growth Factor and CD105-Microvascular Density in Primary Pterygium[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2011-04
4 HAO Shang-Chen From the Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;Changes of cytokines and their receptors in human pterygium[J];眼科新进展;2009-06
5 Li-Na Huang , Xiao-Ming Yao Shenzhen Ophthalmic Center, Medical College of Jinan University, Shenzhen Eye Hospital, ShenZhen, Guangdong Province, China;Inhibitory effect of Meloxicam on the cultured fibroblasts from the excised pterygium[J];国际眼科杂志;2006-01
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZOU Jing;YU Li;XU Bo-Han;SHAO Yi;YI Jing-Lin;Department of Ophthalmology, the Affiliated Eye Hospital of Nanchang University;Department of Ophthalmology, the First Affiliated Hospital of Nanchang University;;Expression of HB-EGF in human pterygium and its significance[J];眼科新进展;2015-03
2 HE Xue-Fei;LIU Gao-Qin;CHEN Zhi-Gang;LU Pei-Rong;Department of Ophthalmology,the First Affiliated Hospital of Soochow University;Graduate School of Medicine of Soochow University;;Effects of topical application of dexamethasone on CCR3 expression in human pterygium and its significance[J];眼科新进展;2014-10
3 YOU Yu-xia;LIANG Qing-feng;MA Ke;Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University;Beijing Key Laboratory of Ophthalmology and Visual Sciences;National Ophthalmic Drug Clinic Evaluation Centera;;The status and prospect of medical treatment on corneal neovascularization[J];国际眼科纵览;2014-02
4 YANG Jie;WEI Yucai;BAO Yongqin;GUO Congrong;ZHAI Ying;YANG Xin;Department of Ophthalmology,the Second Hospital of Hebei Medical University;;EXPRESSION OF TELOMERASE ACTIVITY AND PCNA IN PTERYGIUM[J];河北医科大学学报;2013-12
5 Jin Zhi-tong1,Liu Jun1,Hong Ling-jun2 1Department of Ophthalmology,2Department of Pathology,Qingtian County People's Hospital,Qingtian(323900),China;Clinical Significance of Expression of COX-2 and HIF-1 in Pterygium Tissue[J];放射免疫学杂志;2010-03
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Yan-Hong Hu, Ming-Xin Qi, Sheng Chen Department of Ophthalmology, the Second People's Hospital of Fujian Province, University of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China;Study of liangxue huayu in treatment of CNV in exudative age-related macular degeneration and expression of CCR3 on peripheral blood mononuclear cells[J];国际眼科杂志;2013-03
2 Ding Yi1,Zhang Mingchang2 1Department of Ophthalmology,Wuhan General Hospital of Guangzhou Command,Wuhan 430070,China 2Department of Ophthalmology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;The Expression of CD105 and VEGF in Corneal Neovascularization of Rats[J];华中科技大学学报(医学版);2010-02
3 Hua-hao SHEN~2 Feng XU~2 Gen-sheng ZHANG Shao-bin WANG Wei-hua XU Department of Respiratory Diseases,the Second Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310009,China;CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma[J];Acta Pharmacologica Sinica;2006-12
4 BU Jian-Ping,ZHOU Shan-Bi From the Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical and Science University,Chongqing 400016,China;Expression of VEGF and PEDF in inflammation-associated corn-eal neovascularization and relational study[J];眼科新进展;2006-12
5 XIAO Shi-Yi,YUAN Jing,ZHU Ge-Fei,HU Yan-Hua From the Department of Ophthalmology,the Second Affiliated Hospital of Jinan University,Shenzhen People's Hospital(XIAO Shi-Yi,ZHU Ge-Fei),Shenzhen 518020,Guangdong Province,China;Department of Zhongshan Ophthalmic Center,Sun Yat-sen University(YUAN Jing),Guangzhou 510060,Guangdong Province,China;Department of Ophthalmology,the Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology (HU Yan-Hua),Wuhan 430022,Hubei Province,China;Expression of gelatinase A and vascular endothelial growth factor in pterygia[J];眼科新进展;2006-08
6 Jin Ji,Guan Ming,Ma Jianxing,Liu Zuguo.Department of Ophthalmology,Jinhua Central Hospital,Jinhua 321000,China;Imbalanced expression of PEDF and VEGF in the pterygia[J];眼科研究;2004-05
7 SI Ma jing,MA Jianxing*,FANT James*,LIU Zuguo ** . Dept.Ophthalmology,Shenzhen 2 nd Hospital,Shenzhen 518035 China; * Dept.Ophthalmology,Medical University of South Carolina,Charleston,SC 29425,USA; ** Zhongshan Ophthalmic Center,Zhongshan University,Guangzhou 510060,China;PEDF and VEGF Levels in pterygia,normal cornea and conjunctiva[J];中国实用眼科杂志;2004-05
8 ZHENG Weidong,XU Guoxing,HU Jianzhang,LIN Wen,WANG TingtingFujian ophthalmological institute,The First Hospital,Fujian Medical University, Fuzhou 350005,China;Expression and significance of cell proliferation and apoptosis gene associated protein in pterygium[J];中国实用眼科杂志;2003-09
9 LIU Zuguo(Email:zuguol@gzsums.edu.cn) , XIE Yuhuan, ZHANG Mei, et al Zhongshan Ophthalmic Center, Sun Yat sen University of Medical Sciences, Guangzhou 510060,China;The abnormal expression of epidermal growth factor receptor family in pterygium[J];中华眼科杂志;2000-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved