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《International Eye Science》 2019-04
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Vascular endothelial growth factor and chemokine receptor-3 in the pathogenesis of pterygium

Hui Liu;Min Zhang;Department of Ophthalmology,Xiangyang First People's Hospital Affiliated to Hubei Medical University;  
AIM: To investigate the expression of vascular endothelial growth factor( VEGF) and chem okine receptor3( CCR3) in pterygium.METHODS: The expression of VEGF and CCR3 were detected in 18 patients( 18 eyes) with pterygium and com pared with the norm al conjunctiva epithelium in other14 cases( 14 eyes). The histological differences between the tw o groups were com pared by hem atoxylin and eosin( HE) staining. The expression of VEGF and CCR3 in pterygium and norm al conjunctival tissues were analyzed by im m unofluorescence and im m unohistochem ical. The m RNA expression of VEGF and CCR3 were assessed by Real-tim e PCR.RESULTS: Compared with normal conjunctival tissue,the epithelial layer of pterygium was obvious thickening,the strom al layer was m ore disordered, and the expression levels of VEGF( 0. 69 ± 0. 0875 vs 0. 05 ± 0. 0024)and CCR3( 0.45±0.0248 vs 0.03±0.0074) were significantly elevated( all P 0. 01). The expression level of VEGF m RNA in pterygium was about 12 tim es that of norm al conjunctival tissue( 12. 33 ± 2. 84 vs 1. 00 ± 0. 08),and the expression level of CCR3 m RNA was about 160 tim es as m any as conjunctival tissue( 159.60±34.15 vs 1.00±0.09).CONCLUSION: The expression of VEGF and CCR3 in pterygium was significantly increased, suggesting that they m ay be involved in the occurrence of pterygium and prom ote the developm ent of the disease.
【Fund】: 襄阳市科技局市级科技计划项目(No.2015zd11)~~
【CateGory Index】: R779.6
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