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《International Eye Science》 2019-04
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Progress in animal models of age-related macular degeneration

Tong-Miao Wang;Bo Qin;Shenzhen University;Shenzhen Eye Hospital Affiliated to Jinan University,College of Optometry of Shenzhen University,Shenzhen Key Laboratory of Ophthalmology, Shenzhen City Public Service Plate Form of Ocular Trauma Treatment and Stem Cell Differentiation;  
Age related macular degeneration(ARMD) is the leading cause of blindness in people over 65 years of age. The need for research on effective treatments of ARMD has led to the development of multiple animal models. ARMD is a complex process involving interaction of age, genetic and environmental factors. Animal models have reconstructed many of the histological features in ARMD, making it possible to better understand the underlying pathogenesis of the disease. Although no model can replicate all the phenotypes of human ARMD, it can express different characteristics of ARMD, revealing the roles of chronic oxidative damage, inflammation, immune dysregulation and lipid metabolism in the development of ARMD. This article will reviewthe various ARMD animal models that have been reported. By analyzing the advantages and limitations of each model, it will provide some help for the selection of appropriate animal models for ARMD research and provide new modeling ideas.
【Fund】: 广东省科技计划项目(No.20170211);; 深圳市卫生计生系统科研项目(No.SZLY2017027)~~
【CateGory Index】: R774.5;R-332
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