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《Journal of Clinical Orthopedics and Research》 2018-03
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The incidence of heterotopic ossification after cervical disc replacement in patients with degenerative cervical spondylosis in mainland China: A Meta-analysis

Wang Lifang;Lyu Yanwei;Duan Fangfang;Li Donghang;Tian Wei;Department of Spine Surgery,Beijing Jishuitan Hospital;  
Objective To investigate the incidence of heterotopic ossification in patients with degenerative cervical spondylosis after artificial cervical disc replacement( ACDR) in mainland China by Meta-analysis.Methods The literatures published between January 1997 and October 2016 were collected from both Chinese databases including Chinese Biomedical Literature Database( CBM),China National Knowledge Infrastructure( CNKI),VIP Database and Wanfang Database,and English databases including Pubmed,OVID,Cochrane Library and Embase. Studies providing data of prevalence of heterotopic ossification after ACDR in mainland China were included. The incidence of ectopic ossification was studied by Meta-analysis. Results Fifty-four studies including 39 case-series studies,6 randomized controlled trials and 9 quasi-experiment studies were included in this analysis,and 1 732 samples were involved. The pooled incidence of heterotopic ossification in 6,12,24,36 months after ACDR was 2. 7%( 95% CI: 0. 5%-4. 9%),3. 4%( 95% CI: 1. 9%-4. 8%),8. 3%( 95% CI: 5. 3%-11. 2%) and 11. 2%( 95% CI: 6. 0%-16. 5%),respectively. Conclusion The incidence of heterotopic ossification after ACDR in patients with degenerative cervical spondylosis in mainland China is higher,and increases gradually with the extension of follow-up time.
【Fund】: 国家自然科学基金(81400923);; 北京市医院管理局青年人才培养“青苗”计划(QML20150405);; 北京市医管局使命人才培养计划(SML20150401)~~
【CateGory Index】: R687.3
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