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《The Chinese Journal of Clinical Pharmacology》 2017-16
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Clinical trial of lanthanum carbonate chewable tablets combination with calcium acetate tablets in the maintenace treatment of hemodialysis patients with hyperphosphatemia

YE Hong-ying;ZHANG Ting-ting;HUANG Jian;Department of Nephrology, Jinhua Municipal Central Hospital;  
Objective To evaluate the clinical efficacy of lanthanum carbonate combined with calcium acetate in the treatment of hemodialysis patients with hyperphosphatemia. Methods A total of 70 cases with hemodialysis were randomly divided into treatment group( n = 35) and control group( n = 35). Patients in control group were orally given calcium acetate 667 mg,tid. Patients in treatment group were orally given lanthanum carbonate 250 mg,tid on the basis of control group. All patients were treated for 12 weeks. The clinical effect and levels of phosphorus,cal-cium and intact parathyroid hormone( iPTH) in two groups were observed. Also,the adverse drug reactions in two groups were observed.Results After treatment,the total efficacy rates in treatment group and control group were 91. 43%( 32/35),71. 43%( 25/35),with significant difference( P 0. 05). After treatment,the levels of phosphorus,calcium and iPTH in treatment group were( 1. 73 ± 0. 16) mmol ·L~(-1),( 2. 25 ± 0. 15) mmol·L~(-1),( 189. 60 ± 68. 49) pg·mL~(-1),had significant difference with those in control group,which were( 1. 88 ± 0. 29)mmol·L~(-1),( 2. 45 ± 0. 19) mmol·L~(-1),( 217. 83 ± 64. 00) pg·mL~(-1)( P 0. 05). There were 2 cases of nausea and vomiting in treatment group,with the incidence of 5. 71%( 2/35cases). There was 1 case of abdominal pain in control group,with the incidence of 2. 86%( 1/35 cases,P 0. 05).Conclusion The clinical effect of lanthanum carbonate combined with calcium acetate is great in the treatment of hemodialysis patients with hyperphosphatemia.
【Fund】: 浙江省卫生厅科研基金资助项目(2012KYB227)
【CateGory Index】: R692.5
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