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《The Chinese Journal of Clinical Pharmacology》 2017-16
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Clinical trial of pyridostigmine combined with doxazosin mesylate in the treatment of elderly women with urinary retention after cervical cancer surgery

SU Kun-hua;HU You-bin;MA Jing-ming;KOU Li;Department of Pharmacy,Yichang Central People's Hospital;Department of Obstetrics and Gynecology,Yichang Central People's Hospital;Department of Pharmacy,Enshi Tujia and Miao Autonomous Prefecture Center;Department of Obstetrics and Gynecology, Baoji People's Hospital;  
Objective To evaluate the clinical efficacy and safety of pyridostigmine combined with doxazosin mesylate in the treatment of elderly women with urinary retention after cervical cancer surgery. Methods A total of 52 cases of elderly women with urinary retention after cervical cancer surgery were randomly divided into control group( n = 26) and treatment group( n = 26). Patients in two groups were given routine physical stimulation. Control group was given doxazosin mesylate 4 mg qd. Treatment group was given pyridostigmine bromide tablets 60 mg tid,on the basis of control group. All patients were treated for 7 d. The clinical efficacy,urodynamics and adverse drug reactions were observed in two groups. Results After treatment,the total effective rates in treatment group and control group were 92. 31%( 24/26 cases),65. 38%( 17/26 cases),with significant difference( P 0. 05). After treatment,the residual urine volume,maximum bladder capacity,bladder compliance,maximum urine flow rate,detrusor pressure at maximum urinary flow rate in treatment group were( 40. 14 ± 5. 57) mL,( 300. 19 ± 31. 89) mL,( 32. 00 ± 4. 18) mL·cm H_2O~(-1),( 10. 02 ± 1. 43) mL·s~(-1),( 25. 71 ± 3. 14) cm H_2O,had significant difference with those in control group, which were( 69. 88 ± 8. 37) mL,( 5. 02 ± 0. 53) mL,( 56. 39 ± 6. 19) cm H_2O~(-1),( 17. 89 ± 2. 34) mL·s~(-1),( 33. 41 ± 4. 02) cm H_2O( P 0. 05). The adverse drug reactions in treatment group were nausea and vomiting,diarrhea,total incidence of adverse drug reactions was 15. 38%( 4/26 cases). The adverse drug reactions in control group were nausea and vomiting,diarrhea,the total incidence rate of adverse reaction was 11. 54%( 3/26 cases,P 0. 05). Conclusion Pyridostigmine combined with doxazosin mesylate have significant effect in the treatment of urinary retention after cervical cancer surgery in elderly women,and safety.
【Fund】: 国家医学教育发展中心医学研究课题基金资助项目(2010-35-02-024)
【CateGory Index】: R737.33
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