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《The Chinese Journal of Clinical Pharmacology》 2017-16
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Distribution of etiology and analysis of drug resistance in the patients with cerebrovascular disease complicated with pulmonary infection

ZHANG Ling-hui;YU Xu-hong;FANG Ning-ning;DENG Mei-yu;Department of Respiratory,The People's Liberation Army No.305 Hospital;Department of Pharmacy,The People's Liberation Army No.305 Hospital;  
Objective To investigate the distribution of etiology and the analysis of drug resistance in the patients with cerebrovascular disease complicated with pulmonary infection. Methods A total of 125 patients' sputum specimens with cerebrovascular disease complicated with pulmonary infection were cultured. The distribution of pathogens and antibiotic resistance were analyzed. Results The total 591 strains of pathogenic bacteria which isolated and cultivated for this research were taken from 125 patients' 356 sputum specimens. The top five bacteria were Pseudomonas aeruginosa, Acinetobacter Bauman, Klebsiella pneumoniae,Escherichia coli,Proteus mirabilis. 12 extended-spectrum β-lactamase( ESBL)-producing Klebsiella pneumoniae,19 ESBL-producing Escherichia coli. 56 cases( 9. 48%) showed Gram positive cocci. 424 cases( 71. 74%) showed Gram negative bacilli. The resistance rate of Pseudomonas aeruginosa was 57. 96% to imipenem and about 30% to ceftazidime, ciprofloxacin, gentamicin. The resistance rate of Acinetobacter Bauman was above 70% to ciprofloxacin,ceftazidime,piperacillin/tazobactam,imipenem and gentamicin. The resistance rate of Klebsiellapneumoniae was above 30% to ciprofloxacin, levofloxacin,ceftazidime,aztreonam. The resistance rate of Escherichia coli was above 50% to ciprofloxacin, ceftazidime,gentamicin. Conclusion High incidence of pulmonary infection in elderly patients with cerebrovascular disease. Most of the pathogens were multi drug resistant bacteria.
【Key Words】: pulmonary infection cerebrovascular disease antimicrobial agent Pseudomonas aeruginosa Acinetobacter Bauman
【CateGory Index】: R563.1;R743
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