Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《The Chinese Journal of Clinical Pharmacology》 2017-16
Add to Favorite Get Latest Update

Protective effects of ginsenosides on the levels of tumor necrosis factor-α,interleukin-6 and interleukin-10 in rats with acute lung injury

JI Yu-hong;HUANG Sen-sen;GONG Xiu-li;MAO Yi-min;Department of Respiratory Medicine,Luoyang Oriental Hospital;Department of Respiratory Medicine,The First Affiliated Hospital of Henan University of Science and Technology;  
Objective To study the protective effects of ginsenoside on endotoxin of lipopolysaccharide( LPS)-induced acute lung injury( ALI)in rats. Methods Adult rats were divided into 4 groups( 10 rats in each group) : blank group( 0. 9% Na Cl),model group,ginsenoside group( 100 mg·kg~(-1)) and control group( methylprednisolone 40 mg·kg~(-1)).Intraperitoneal injection of LPS( 5 mg·kg~(-1)) to prepare the ALI model of rats. The drugs given at the time of 3 d and 1 d respectively before established model in ginsenoside group and control group. The oxygenation index( PO_2/FiO_2),and protein content in bronchoalveolar lavage fluid( BALF) were detected. The levels of tumor necrosis factor α( TNF-α),interleukin 6( IL-6) and interleukin 10( IL-10) in BALF were detected by ELLISA. Results PaO_2/FiO_2:Compared with the blank group( 485. 49 ± 20. 71) mmHg,model group was( 269. 29 ± 13. 61) mmHg with statistically significant( P 0. 01). Compared with the model group,ginsenoside group and control group were( 379. 74 ± 15. 06),( 398. 08 ± 16. 89) mmHg with statistically significant( all P 0. 01). Protein content of BALF: Compared with the blank group( 39. 00 ± 5. 00) μg · mL~(-1),model group was( 3. 69 ± 3. 86) μg · mL~(-1)with statistically significant( P 0. 01). Compared with the model group,ginsenoside group and control group were( 77. 00 ± 6. 00),( 97. 00 ± 11. 00) μg·mL~(-1)with statistically significant( all P 0. 01). Levels of TNF-α,IL-6 and IL-10 of BALF: Compared with the blank group( 218. 85 ± 7. 36),( 10. 84 ± 1. 66),( 50. 00 ± 7. 21) ng · L~(-1),model group were( 505. 78 ± 7. 60),( 61. 55 ± 4. 08),( 94. 76 ± 3. 58) ng · L~(-1)with statistically significant( all P 0. 01).Compared with the model group,ginsenoside group and control group were( 346. 42 ± 11. 24),( 338. 14 ± 5. 37)ng·L~(-1);( 42. 49 ± 1. 26),( 40. 07 ± 2. 60) ng·L~(-1);( 114. 22 ± 2. 58),( 119. 07 ± 4. 08) ng·L~(-1)respectively with statistically significant( all P 0. 01). Conclusion Ginsenoside may improve the ALI rats by up regulating the expression of anti-inflammatory factors( IL-10) and down regulating the expression of inflammatory factors( TNF-α and IL-6).
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved