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《The Chinese Journal of Clinical Pharmacology》 2017-16
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Study on anti-fatigue and hypoxia tolerance function of Jasmine leaves' water extract in mice

LIANG Xun-jie;HUANG Xiao-xia;LU Mian;BI Yuan-sheng;TANG Ya-ting;LIN Meng-yao;HUANG Suo-yi;College of Clinical Medicine,Youjiang Medical University for Nationnalities;College of Pharmacy,Youjiang Medical University for Nationnalities;Guangxi Colleges and Universities Key Laboratory of The Characteristics of Ethnic Medicine of The Youjiang Valley,Youjiang Medical University for Nationnalities;  
Objective To study on the anti-fatigue and hypoxia tolerance function of Jasmine leaves' water extract in mice.Methods Forty-eight normal male mice were averagely selected and divided into four groups by weight: blank control group,low concentration experimental group,medium concentration experimental group and high concentration experimental group. Jasmine leaves' water extract of different concentrations( 0,200,400,600 mg·mL~(-1)respectively for the four groups) was given into the mice's stomach for a continuous 16 days,each mice was given 10 mL·kg~(-1)a day. Burdened swimming test and hypoxia tolerance test were conducted in the mice to determine their swimming time and death time. The liver weight coefficient was calculated. Results The burdened swimming time: Compared with blank control group 9. 27 min,that were 9. 41,15. 42,10. 63 min in low,medium,high concentrations experimental groups respectively while medium experimental group had significantly( P 0. 05). The hypoxia tolerance time: Compared with blank control group( 47. 56 ± 5. 61) min,that were( 56. 24 ± 10. 99),( 47. 20 ± 4. 51),( 53. 44 ± 7. 56) min in low,medium,high concentrations experimental groups respectively while low experimental group had significantly( P 0. 01). The liver weightcoefficient: Compared with blank control group( 4. 84 ± 0. 29) × 10~(-2),that were( 5. 20 ± 0. 72) × 10~(-2),( 5. 43 ± 0. 39) × 10~(-2),( 5. 42 ± 0. 57) × 10~(-2) in low,medium,high concentrations experimental groups respectively while medium,high experimental groups had significantly( all P 0. 01). Conclusion Jasmine leaves' water extract is proved to have anti-fatigue and hypoxia tolerance function in mice.
【Key Words】: Jasmine leaves'water extract anti-fatigue hypoxia tolerance liver weight coefficient swimming
【Fund】: 国家自然科学基金资助项目(81160347);; 百色市科学研究与技术开发计划第一批基金资助项目(百科计1001013)
【CateGory Index】: R285.5
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