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《The Chinese Journal of Clinical Pharmacology》 2017-16
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Analysis of uses drugs in inpatients with hypertesive disorders of pregnancy

YAN Chun-mei;ZOU Wen;HONG Fan-zhen;XU Yong-ping;JIA Hong-ying;LIU Huan-di;ZHANG Ying-hui;XIAO Juan;ZHANG Yuan;Department of Obstetrics,Second Hospital of Shandong University;School of Medicine,Shandong University;Department of Pharmacy,Second Hospital of Shandong University;Center of Evidence-based Medicine,Second Hospital of Shandong University;Information Center,Second Hospital of Shandong University;Department of Medical Recored,Second Hospital of Shandong University;School of Public Health,Shandong University;  
Objective To retrospectively investigate the drug use of the patients with hypertensive disorders of pregnancy( HDP) so as to evaluate the rationality of the drug use among these patients. Methods The information of the inpatients with HDP as the initial diagnosis in this hospital from January 2011 to June 2015 was collected,including the patient characteristics,drug use,costs,etc. The data was analyzed by the SPSS22. 0 software. Results In sum,974 HDP cases were included,among which severe preeclampsia is the main component with 38. 81%( 378/974 cases). Drug analysis showed that there were four types of anti-hypertensive drugs,three preeclampsia-prophylaxis drugs,three sedatives,one diuretic, one anti-hypoalbuminemia drug, and one Chinese medication. The patients were divided into subgroups according to HDP classification and there was subtle difference among the subgroups. The top ten drugs according to the use frequency were vitamin C,vitamin E,nifedipine,ligustrazine,magnesium sulfate,nifediping sustained-release tablets, albumin, diazepam, urapidil, and furosemide. Conclusion The HDP treatments were mainly composed by the preeclampsia prophylaxis and the anti-hypertension. Ligustrazine acted as an adjunctive treatment. The treatments above were consistent with the guidelines,which was rational. But the use of Vitamin C and E was controversial.
【Fund】: 山东省自然科学基金资助项目(ZR2014HP029)
【CateGory Index】: R714.246
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