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《The Chinese Journal of Clinical Pharmacology》 2017-16
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Analysis of efficacy and safety of carboprost tromethamine in the treatment of postpartum hemorrhage

SHI Rui;ZAHO Ke-xin;CHEN Li-fang;YANG Xiao-liang;Department of Pharmaceutical, Central Hospital of China National Petroleum Corporation;Department of Gynaecology and Obstetrics, Central Hospital of China National Petroleum Corporation;Medical Office, Central Hospital of China National Petroleum Corporation;  
Objective To evaluate the efficacy and safety of carboprost tromethamine in the treatment of postpartum hemorrhage.Methods Pub Med,Cochrane Library,EMbase,CNKI,Chinese VIP information database and Wanfang data were retrieved to collect the randomized controlled trial( RCT) of carboprost tromethamine( treatment group) vs. oxytocin( control group) in the treatment of postpartum hemorrhage. The data including age,drug regimen,blood loss volumes and adverse reactions were extracted and the quality was evaluated by RevMan 5. 0 software. Results A total of 25 studies involving 4503 patients( treatment group 2266; control group 2237) were included. Meta-analysis indicated that the mean difference in blood loss volumes during the operation and 2 h and 24 h after operation of the patients were -75. 62,-105. 50 and -116. 89,respectively. The blood loss volumes in treatment group were far less than control group,with statistical significance( all P 0. 001). The mean difference between control and treatment groups with the hemoglobin decrease was -2. 07. The control group were significantly lower than treatment group( P 0. 001). After the drugtreatment,the incidence rate of postpartum hemorrhage were 8. 94%( 164/1834 cases) and 18. 38%( 334/1817cases),respectively. The incidence rate of nausea and vomiting were 13. 73%( 171/1245 cases) and 8. 70%( 108/1241 cases) with statistical significance( P 0. 001). Conclusion Carboprost tromethamine has better efficacy in the treatment of postpartum hemorrhage patients,which can reduce the incidence of bleeding,but increase the incidence of nausea and vomiting.
【Key Words】: carboprost tromethamine oxytocin postpartum hemorrhage efficacy safety Meta-analysis
【Fund】: 廊坊市科技计划支撑基金资助项目(2014013019)
【CateGory Index】: R714.461
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