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《Journal of Functional Polymers》 1988-01
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Syntheses and Antitumor Activity of Poly[polymethylene N- (5 -fluorouracil-1-acetyl) aspartamides]

Zhuo Renxi, Fan Changlie, Wu Bin (Dept. of Chem., Wuhan University, Wuhan)  
Six poly (polymethylene N-(5-fluorouracil-l-acetyl) aspartamides) were synthesized by the condensation of di-p-nitrophenyl N-(5-fluorouracil-1-acetyl) aspartate with a series of polymethylene diamincs and with tye ethyl ester of lysine. All of the polyamides obtained wcrc structurally characterized by ~1H NMR, IR and UV spectra as well as elementary analyses. The antitumor activity of the polyamides were tested against Ehrlich ascites carcinoma in mice. Ⅴ 4 and Ⅵ showed an inhibi(?)on rate of 31.85%, 44.25% respectively.
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