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《Journal of Functional Polymers》 2008-04
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Preparation,Characterization and in vitro Release Behaviour of BSA Loaded Microcapsules

WANG Kan,ZHANG Yan,BIAN Qing-qing,LANG Mei-dong(Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China)  
Bovine serum albumin(BSA) loaded poly(ethylene glycol)-block-poly(ε-caprolactone-cobenzyl(7-oxooxepan-2-yl) acetate)(PEBCL) microcapsule was prepared by W/O/W double emulsion-solvent evaporation technique.The structure of the polymer and preparing conditions which influence the microcapsule size,the drug loading and entrapment efficiency were investigated.The mean particle size of microcapsules is in the range of 13-30 μm.The drug loading efficiency and encapsulation efficiency can be achieved as high as 14.18% and 75.90%,and the release behavior can be well-controlled.PEBCL microcapsules might have great potential as carriers for protein drugs.
【Fund】: 国家自然科学基金(20374013)
【CateGory Index】: R94;R318.08
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