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Neuroprotection of rhEPO on Cerebral Ischemia in both Normal and Pentylenetetrazol-induced Acute Diabetic Rats

LU Yang~*,DONG Qiang,REN Hui-min.~*Department of Neurology,Huashan Hospital,Fudan University,shanghai 200040,China  
Objective:To observe the influence of rhEPO on the neurological deficits,infarction territory proportion in focal cerebral ischemic rats with acute DM disease,and to compare these results with those of normal cerebral ischemic rats.Methods:The experimental animals experienced 1 hour of middle cerebral artery occlusion(MCAO) before reperfusion.A certain volume of rhEPO was injected at the same time of reperfusion.Longa and NSS tests were performed to value neurological function and the infarction territories were shown through crystal-violet staining.Results:In the normal rats,rhEPO can significantly improve the NSS by(4.17±4.88)、(2.67±3.01)、(1.83±1.72) respectively(P0.05);while in the acute DM ones,rhEPO can significantly improve them by(2.50±1.77)、(1.88±2.42)、(2.00±0.93) respectively as well (P0.05).At the 1st day after reperfusion,there was no difference between the Longa of DM control group and that of normal control((P)0.05),while the Longa at the 7th,14th day after reperfusion of DM control group were significantly higher than those of normal control(P0.05);At the 1st,7th,14th day after reperfusion,the NSS of DM control group were all significantly higher than those of normal control(P0.01).In the normal rats,the treatment of rhEPO can reduce infarction territory at the different three time points by(52%±7%)、(62%±7%)、(76%±3%) respectively(P0.05 or 0.01),while in the acute DM ones,the reduction of infarction were(50%±7%)、(57%±5%)、(69%±6%) respectively(P0.01).The changes in the acute DM rats were of no significance when referred to those in the normal(P0.05).At the 1st,7th,14th day after reperfusion,the proportion of infarction part of the DM control group was significantly larger than those of normal control((P)0.01). Conclusion: rhEPO can significantly ameliorate the neurological deficit and reduce the infarction area in the rats with focal cerebral ischemia in both groups with a similar pattern.The neurological deficits of focal cerebral ischemic rats with acute STZ-induced DM were significantly severer than those of the normal ones.
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