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The Observation of SS,AVP,β-EP and NSE in CSF of Patients with Vascular Dementia

SUN Wei-ya.Department of Neurology,Heze Municipal Hospital,Heze 274031,China  
Objective: The clinical significance of SS, AVP,β-EP,and NSE in CSF of patients with vascular dementia(VD) has been observed.Methods:MMSE,Hachinski Ischemic Scale(HIS) and Function Active Questionnaire(FAQ) were used to evaluate 60 patients with VD,70 cases with cerebral infarction without dementia and 30 controls.The contents of SS,AVP,and β-EP in CSF were determined by Radio-immunization analysis.ELISA was applied to measure the content of NSE in CSF.Results: The contents of SS,AVP,β-EP,and NSE in CSF were significantly decreased in VD patients(P 0.01),whereas AVP and NSE were significantly increased in the infarcted patients(P0.01).Conclusion: The VD patients show a tendency of low contents of SS,AVP,β-EP,and NSE in CSF.Monitoring those parameters could help the early recognition of VD,and could be helpful in staging the disease.
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