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A Paracrine Effect of Adenovirus with NURR1 Gene (Ad-NURR1) on Differentiation of Neural Stem Cells

LI Qing-jun,XIAO Song-hua,XIAO Wei-ming,JIANG Dong-xing.Department of Neurology,Dong Guan People Hospital,Dongguan 523018,China  
Objective:To study the paracrine effect of adenovirus with NURR1 gene(Ad-NURR1)on differentiation of C17.2 neural stem cells.Methods:Nurr1 protein excreted by Ad-NURR1 was probed by Western blotting.Differentiation of C17.2 cells induced by Nurr1 protein was tested by paracrine trials.Result:Nurr1 protein could be secreted into supernatant of C17.2 cells to enhance them to differentiate into neurons.Conclusion:Nurr1 protein can be excreted and could induce differentiation of C17.2 cells.
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