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Clinical Characteristics of Paroxysmal Kinesigenic Choreoathetosis

KANG Hui-cong,HU Qi,LIU Xiao-yan,XU Feng,WANG Xia,ZHU Sui-qiang.Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Techology,Wuhan 430030,China  
Objective:Clinical characteristics and efficacy of AEDs of paroxysmal kinesigenic choreoathetosis(PKC)have been analyzed.Methods:Thirty-one patients with PKC were recruited and clinically analyzed.Results:The average age of the first attack is 16.8 years old and the pinnacle is 10 to 20 years old.Sudden movement is the most common provocative causes(92%).The whole attack lasts less than 1 minute,manifested by muscle tension disturbances(83.9%),movement-like dancing(16.1%),abnormal movements of the mouth and face and other symptoms(16.2%).The attacks tend to be very frequent and 71% of patients experience more than one attack per day.EEG and neuroimaging study showed no abnormalities in most patients.Low dosage of anti-epilepsy drugs(AEDs)can control the attacks in 50 %-77.3 % of the patients.Conclusion:PKC is a common movement disorder in the neurological diseases.The AEDs is very effective.Differentiation between epilepsy and PKC needs our attention,and further clinical research in this disorder is necessary.
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