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Difference of Cyclin-dependent Kinases in Astrocytes and Neurons during Development and Aging at Hippocampus of Rat

WANG Jing,WANG Fang,ZHANG Qiong,ZHU Li-xia,WANG Wei.Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Techonology,Wuhan 430030,China  
Objective: To study the difference of CDKs in astrocytes and neurons in development phase at hippocampus of rat.Methods: Hippocampus of rats at the age of 1 day,11 days,3 months and 13 months,were harvested to detect the CDKs of astrocytes and neurons in hippocampus by flow cytometry method.Results: In astrocytes,the expression of CDK1 at 1 day was remarkably less than it at 11 days,3 months and 13 months(P0.05).And there were no apparent changes in the expression of CDK2 and CDK4 in the astrocytes of all the 4 groups.In neurons,the expression of CDK1 at 11 days was highest and remarkablely upregulated than it at 1 day(P0.05).The expression of CDK2 in the neurons increased while aging,and there was apparent change between 1 day and 13 months(P0.05).And there were no apparent changes in the expression of CDK4 between each group.Between in the astrocytes and the neurons,there was apparent change in the expression of CDK1 of 11 days,3 months and 13 months(P05),and in the expression of CDK4 of 1 day and 11 day.Conclusion: CDK1,CDK2 and CDK4 are involved in the astrocytes and neurons in all the developmental stages of rat hiappocampus.
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