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Alterations of Behavior and Hypothalamic Gastrin-releasing Peptide mRNA Expression in Rats following Chronic Unpredictable Mild Stress

XIAO Zhe-man,YAO Li-hua,GUO Qing-shan,PENG Liang,YANG Can,LIU Zhong-chun.Department of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060,China  
Objective:To investigate the changes of behavior and expression of hypothalamic gastrin-releasing peptide(GRP) mRNA after chronic and unpredictable mild stress(CUMS).Methods:Fourteen rats were randomly divided into control group(n=7) and depression group(n=7).The rats in the depression group were subjected to CUMS for 21 consecutive days.The behavior of 2 groups were observed.The expression of GRP mRNA was measured by real-time quantitative PCR.Results:The autonomic activity and sugar consumption in the depression group were significantly lower than those in the control(P0.001).The total distance,speed and rearing were significantly reduced in the stress group,revealed by the open field test(P0.001).The expression of GRP mRNA in the stress group was significantly higher than that in the control group(P0.05).Conclusion:The up-regulation of GRP mRNA probably plays a key in the behavior changes in rats exposed to stress.
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