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Clinical Study of Efficacy and Safety of Olanzapine Tablets on Patients with Psychotic Disorders after Brain Trauma

LU Yun,ZHAO Sha-sha,XU Jin-zhi.Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China  
Objective: To evaluate efficacy and safety of Olanzapine tablets on patients with psychotic disorders after brain trauma.Methods: Sixty-eight cases were treated with Olanzapine.Brief psychiatric rating scale(BPRS),clinical global impression(CGI) and treatment emergent symptom scale(TESS) were used to assess the symptoms of patients at the beginning and 2,4,8 weeks after treatment.Results: Among the 68 cases,60 had the integrated data.Compared with those at the beginning of treatment,the scores of BPRS and CGI were significantly decreased at 2,4 and 8 weeks after treatment(P0.05).The total effective rate was 95%.Side effects,such as nausea,weight gain and slightly elevated glucose level,were detected in only two cases.Conclusion: Olanzapine is a useful antipsychotic with few side-effects for patients with psychotic disorders after brain trauma.
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