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Effects of 5-hydroxytryptamine 1A Receptor Agonists on Hereditary Cerebellar Ataxia:A Meta-analysis

MAO Xu-qiang,ZHANG Jian-ping,CHENG Wei-guo,YU xuan,LI Zai-wang.Department of Neurology,Wuxi People's Hospital of Nanjing Medical University,Jiangsu 214023,China  
Objective: To explore the effect of 5-hydroxytryptamine 1A(5-HT1A) receptor agonists on hereditary cerebellar ataxia.Methods: The reports were obtained based on selection criteria.According to Meta-analysis method,the RevMan 4.3.2 software was applied to estimate the Standard Means Deviation(SMD)and 95% Confidence Interval(CI) of improving the cerebellum functional score between 5-HT1A receptor agonists treatment group and placebo control group.Results: The SMD and 95% CI of improving the cerebellum functional score between the two groups were-0.36,and(-2.29,1.59)respectively.There was no significant difference in the outcome between the two groups(Z=0.36,P=0.359).Conclusion: The current clinical data could not confirm that 5-HT1A receptor agonists could effectively ameliorate the symptoms of hereditary cerebellar ataxia.Key kords:5-HT1A receptor agonists;hereditary cerebellar ataxia;Meta-analysis
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