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《Neural Injury and Functional Reconstruction》 2014-01
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Impairment of Nesting Behavior in Tg-SwDI Mice

MIN Zhe;WANG Shu-nan;WU Jun;HUANG Xiao-jiang;FANG Yu;QIU Zhan-dong;ZHANG Su-ming;Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;  
Objective:To investigate the differences in the nesting behaviour between Tg-SwDI transgenic mice and wild-type(WT) mice. Methods: Transgenic Tg-SwDI(Tg) and wild-type(WT) mice have been studied to observe their group nest-building behaviors with chip shavings and individual nest-building behaviors with paper towels. Results: The genotype(F1,31=37.03,P0.0001)and age(F2,31=3.88,P0.05)had effect on the group nest construction, and the same on the individual nest-building. However, there were no significant differences between Tg and WT mice until 18~20 months. Conclusion: The Tg-SwDI transgenic mice showed a worse nesting compared to WT mice at the early ages when they were group-housed. Most individually housed mice in each group showed impaired nesting behavior in old age(18~20 months).
【Fund】: 国家自然科学基金(No.81271407)
【CateGory Index】: R749.16
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