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《Neural Injury and Functional Reconstruction》 2014-01
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Laser Speckle Imaging of Mice Cerebral Blood Flow and Cortical Infarction

FANG Yu;QIU Zhan-dong;MIN Zhe;XIONG Yong-jie;HU Wen-tao;HUANG Liang-Jiang;ZHANG Su-ming;Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;  
Objective:To explore the application of laser speckle imaging in monitoring C57BL/6 mice cerebral blood flow under normal condition and the photochemical infarction. Methods: Eight 8~10 weeks male C57BL/6mice were used for blood flow detection. The cortex blood flow of the C57BL/6 mice was monitored by laser speckle imaging system for 30 minutes. Five 8~10 weeks male C57BL/6 mice were induced cortical photochemical infarct while five 8~10 weeks male C57BL/6 mice in sham group received sham operation. Laser speckle imaging was preformed before and 24 hs after the surgery. Results: Eight C57 mice can be detected cerebral blood flow imaging with high image quality without damaging the skull. The small blood vessels can be observed by this system. In the photothrombosis group, small blood flow was decreased or disappeared on the cortex of mice using laser speckle image. Conclusion: The image of C57 mice brain cortical blood flow could be obtained by laser speckle imaging with high spatial and temporal resolution.
【Fund】: 武汉市科技计划项目(No.2013060501010159)
【CateGory Index】: R743
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1 REN Jie,CHEN De-fu,WANG Ying,GU Ying* Department of Laser Medicine,PLA General Hospital,Beijing 100853,China;Recent Advances in Optical Imaging Techniques for Clinical Assessment of Port Wine Stains[J];Chinese Journal of Laser Medicine & Surgery;2013-04
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