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Correlation between Fibrinogen and Mean Platelet Volume levels and Acute Cerebral Infarction

WU Zhe;HAN Deng-feng;ZHANG Xiao-ning;Department of Neurology, The First Affiliated Hospital of Xinjiang Medical University;  
Objective:To investigate the relationship of fibrinogen(FIB), mean platelet volume(MPV) and acute cerebral infarction(ACI). Methods: The level of platelets system platelets(PLT), MPV, plateletcrit, platelet distribution width(PDW) and the coagulation system(prothrombin time, international normalized ratio, FIB, activated partial thromboplastin time) of 429 ACI cases(ACI group) and 429 cases of Non-cerebral infarction group(control group) were analyzed. According to the National Institutes of Health stroke Scale(NIHSS) in ACI patients, the ACI group was divided into mild, moderate and severe subgroups. Results: Compared with the control group, the PLT levels were significantly lower(P0.01) whereas the MPV, PDW and FIB levels were significantly higher(P0.01) in ACI group. Logistic regression analysis showed that MPV and FIB were independently associated with ACI(OR = 1.628, 95% CI :1.427~1.857; OR = 7.115,95% CI :4.981~10.164). The FIB level showed no significant correlation with MPV level. The FIB levels between the subgroups of ACI group were significantly different(P0.01). In ACI patients, the FIB levels and NIHSS score were positively correlated(r =0.451, P0.01). Conclusion: FIB and MPV levels may be the important risk factors for ACI.
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