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《Neural Injury and Functional Reconstruction》 2014-01
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Application of SPECT Combined with Serum S100β Protein in the Diagnosis of Vascular Cognitive Impairment

LIU Liang;WANG Wen-jing;WANG Qian-you;Department of Neurology, The Affiliated Provincial Hospital of Anhui Medical University;  
Objective:To explore the application of SPECT combined with serum S100β protein in the diagnosis of vascular cognitive impairment but not dementia(VCIND). Methods: Sixty VCIND patients(VCIND group)and 30 healthy persons(control group) have been evaluated by general examination, nerve function evaluation,brain SPECT examination and serum S100βprotein content detection. Results: Compared with the control group,rCBF in the bilateral frontal lobes, left superior lobule, and the left thalamus of VCIND group was decreased significantly(P0.05). Compared with the right side, rCBF in the frontal lobe, superior lobule, and the thalamus on the left side were decreased significantly(P0.05). The serum S100β protein content in the VCIND group was increased significantly compared with that in the control(P0.05). Conclusion: SPECT cerebral perfusion imaging combined with serum S100β protein detection is effective in the early diagnosis of VCIND patients.
【Fund】: 安徽省卫生厅课题(No.13zc032)
【CateGory Index】: R743.3
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