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《Neural Injury and Functional Reconstruction》 2014-01
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Application of Magnetic Resonance Imaging in Diagnosis of Multiple System Atrophy

LIN Zhi-jian;CHEN Xu-hui;CHE Xiu-juan;ZHANG Hai-ou;WU Jun;Department of Neurology, Peking University Shenzhen Hospital;  
Objective:To explore the application of magnetic resonance imaging(MRI) in diagnosing multiple system atrophy(MSA) and distinguishing MSA from PD. Methods: Twenty-six consecutive patients with MSA,20 consecutive patients with PD and 18 healthy control subjects were examined with MRI. The imaging changes focused on the presence or absence of brain atrophy including the cerebellum, pons, medulla oblongata and putamen atrophy, cruciform hyperintensity of the pons, slit-like hyperintensity in the posterolateral margin of the putamen, hyperintensity of the MCP, and hypointensity of the putamen. Measurements of the MCP width were performed in all subjects. Results: All patients with MSA had different severity of atrophy in the cerebellum,pons, medulla oblongata and/or putamen. Cruciform hyperintensity of the pons was found in 15 cases with MSA;hyperintensity of the MCP in 6 cases with MSA; slit-like hyperintensity in the posterolateral margin of the putamen in 8 cases with MSA; and hypointensity of the putamen in 4 cases with MSA respectively. The MCP width was significantly smaller in MSA group(6.4±1.4)mm than that in PD group(9.2±1.1) mm or control group(9.4±0.8)mm. The average MCP width in 15 MSA patients with cruciform hyperintensity was significantly lower(5.3±1.0)mm than that in 11 MSA patients without cruciform hyperintensity(7.2±1.6 mm)(P0.05). Conclusion: The MR imaging is useful for diagnosing MSA. Measurement of MCP width on MR images is helpful for distinguishing patients with MSA from those with PD.
【Fund】: 深圳市科技研发资金(No.JCYJ20130402114702121)
【CateGory Index】: R445.2;R741.04
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