Effects of Isoliquiritigenin on Serum Cytokine levels in Rats after Traumatic Brain Injury
YANG Yong-ming;LI Zhi-yun;JI Wei;Department of Neurosurgery, Lanzhou General Hospital, Lanzhou Command, PLA;
Objective:To observe the effects of isoliquiritigenin on levels of serum IFNγ, MCP-1, IL-2, IL-4 and IL-13 in rats after traumatic brain injury(TBI). Methods: Forty-five rats were randomly divided into shamoperated, model and treatment groups with 15 rats in each group. The TBI model was established with the modified Feeney's method. In the rats in the sham-operated group the skull was just window-opened but without any blow. After the operation, the animals in treatment group were given isoliquiritigenin, while the rats in the sham-operated and model groups were given the same volume of normal saline. On day 5 after TBI, the serum cytokines were measured and brain water content was determined. The morphology of neurons in hippocampus was observed. Results: When compared with the model group, the level of IFNγ in the treatment group was decreased(P0.05), while the levels of MCP-1,IL-2,IL-4 and IL-13 in the treatment group were increased(P 0.05). The water content of brain in the treatment group was decreased compared to that in the model group(P 0.05). And compared with the model group, the morphology of hippocampus was improved(P0.05).Conclusion: Isoliquiritigenin can promote brain tissue rehabilitation in rats after TBI, perhaps mediated by modulation of cytokines.