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Correlation between Single Nucleotide Polymorphism of-1195G >A of COX-2 Gene and Aspirin Resistance in Patients with Ischemic Stroke

CHEN Zhong-yun;LI Shan-shan;LI Jing;XU Zhi-wei;YANG Xu;Department of Neurology, Aerospace Center Hospital, Aerospace Clinical Medical College affiliated to Peking University;  
Objective:To study the correlation between single nucleotide polymorphisms(SNPs) of-1195GA of cyclooxygenase-2(COX-2) gene and Aspirin resistance(AR) in patients with ischemic stroke(IS). Methods: According to the rate of platelet aggregation, 210 northern Chinese Han patients with IS were divided into Aspirin sensitivity(AS) group(147 cases) and non-Asgroup[17 AR cases, and 46 Aspirin semi-resistance(ASR) cases](n=63). The SNPs were detected by Amplification mutation system(ARMS) combined with TaqMan probe in a real-time PCR. Results: There were no significant differences in the genotype, allele, additive or recessive model frequencies of-1195GA polymorphisms between the 2 groups. The significant difference between(GA+AA) and GG genotype frequencies of-1195GA polymorphisms were observed in groups of AS and non-AS(P=0.03). For A allele of-1195GA, there was also a significant difference between the two groups(P=0.02). On multivariate analysis controlling for conventional vascular risk factors, the-1195 GA and AA genotypes were identified independently to be related with(ASR+AR)(OR=2.41, 95%CI: 1.07~5.42, P=0.03). Conclusion:-1195GA polymorphism of COX-2 gene was associated with AR or ASR in patients with IS, which may be a genetic predisposition to phenotypes of AR or ASR.
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