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Clinical Application of ABCD2 Score in Predicting Evolution of Transient Ischemic Attack into Cerebral Infarction

SONG Lin;WEI Heng;XU Kang;ZHOU Rui;GUO Zhen-li;DU Ji-chen;Department of Neurology, Xinhua Hospital;  
Objective:To explore the clinical efficacy of ABCD2 score in predicting transformation of transient ischemic attack(TIA) into cerebral infarction(CI) within 7 days. Methods: According to occurrence of CI 7 days after TIA, 115 TIA patients were divided into CI group(n=33) and non-CI group(n=82). Risk factors of cerebrovascular diseases and ABCD2 scores were documented. Single factor and multivariate analysis have been used to explore the differences in risk factors and ABCD2 score contents between the two groups. Receiver operating characteristic curve(ROC) analysis was used to explore the efficacy of ABCD2 score as well. Results: The age and ABCD2 score in the CI group were significantly higher than those in the non-CI group(P0.05 or P0.01). On single factor analysis showed that, in the CI group, the proportion of patients older than 60 years, systolic blood pressure higher than 140 mmHg and/or diastolic pressure higher than 90 mmHg, unilateral limb force weak, duration of symptoms longer than 60 min were significantly higher than that in the non-CI group(P0.05). In addition, in the CI group, the proportion of patients whose symptoms persisted for 10~59 min was much less than that in the non-CI group(P0.05). Multivariate analysis showed the same results. ROC analysis showed that ABCD2 score of 4.5 was promised point in predicting TIA evolving into CI within short-term. The area under curve was 0.73 with sensitivity of 57.6% and specificity of 78.0%, Conclusion: ABCD2 score was a simple and effective tool to predict whether TIA will evolve into CI in short-term. ABCD2 score above 5 might have an important predictive value.
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