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Application of Perfusion CT in Predicting Clinical Outcome of Patients with Acute Cerebral Infarction

ZHANG Wei-hua;LIU Nan;CHEN Hui;ZHANG Wei-wei;ZHU Guang-ming;Department of Neurology, General Hospital of Beijing Military Region, PLA;  
Objective:To investigate the correlation between the variables conducted by Perfusion CT(PCT) and clinical outcome of acute cerebral infarction. Methods: In all, 78 patients with anterior circulation acute cerebral infarction were enrolled in this observation. Their infarct core and penumbra were accessed by PCT. Modified Rankin scale(mRS) was used to followe up the participants 90 days after onset. The correlation between Perfusion CT and clinical outcome was analyzed by multi-variables linear regression analysis. Results: Age was the most important factor to predict the clinical outcome(P0.01). Both NIHSS and HMCAS were negatively correlated with 90-days mRS(P=0.021 and 0.038). When compared with the ICA occlusion, patients with M1 occlusion had relatively better prognosis(P=0.012). Recanalization of vessels was a significant factor affecting the prognosis(P=0.010). The infarct volume in PCT could not accurately predict the prognosis(P=0.145), and the penumbra volume in PCT was positively correlated with prognosis(P=0.044). Conclusion: PCT is useful in deciding the therapeutic strategy and predicting the outcome in early stage of acute cerebral infarction patients.
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