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Tamoxifen Inhibits the Migration and Activation of Microglia after Oxygen-glucose Deprivation

HAN Qing-dong;LIU Sheng-wen;SUN Wei;XIE rui-fan;LEI Ting;CHEN Jin-cao;ZHANG Hua-qiu;Department of Neurosurgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology;  
Objective: To observe the effects of tamoxifen(TAM) on the migration and proliferation of BV-2 cells in oxygen-glucose deprivation(OGD) models. Methods: BV-2 cells were divided into control group(normal oxygen concentration+ high glucose+ fetal bovine serum free medium), OGD group(1% oxygen + sugar free+ serum-free medium), OGD+TAM group(1% oxygen + sugar free+serum-free medium +TAM). After performing scratch test, migration and proliferation of BV-2 cells were examined by photographs and immunohistochemistry. Results: BV-2 cells in the OGD group shown faster migration than those in the control group(P0.05). The administration of TAM suppressed the migration of BV-2 cells compared to the OGD group(P0.05). The percentage of Ki67 positive cells in the OGD group was higher than that in the control group, and the application of Tam reduced the percentage of Ki67 positive cells compared with that in the OGD group(P0.05). Conclusion: Tamoxifen may play a neuro-protective role in hypoxic condition by suppressing the migration and proliferation of BV-2 cells after OGD.
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