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Roles of Ginsenoside Rg1 in the Induction of Mouse Induced Pluripotent Stem Cells

HU Wen-tao;YAN Qiu-yue;FANG Yu;QIU Zhan-dong;ZHANG Su-ming;Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology;  
Objective:To observe the effects of Ginsenoside Rg1 on the induce efficiency of mouse induced pluripotent stem cells(iPSCs) from Mouse embryonic fibroblasts(MEF). Methods: The cells were infected with classic retro-viruses vector expressing classic 4 factors, then Ginsenoside Rg1(0、0.3、1、3、10 μg/mL) was added to the MEF medium during the first 3 days after infection. Then the clones were identified. Results: Ginsenoside Rg1(1 μg/mL)can obviously improve the induction efficiency of iPSCs [(0.0450±0.0019)% in the Ginsenoside Rg1group vs(0.0100±0.0033)% in the control group)]. The clones were positive. Conclusion: Ginsenoside Rg1 may facilitate the inducing efficiency of iPS cells.
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