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Effects of Xiaoyaosan on Mice Model of Alzheimer's Disease with Stagnation of Liver-QI

WU Lei-bin;QIU Xin;CHEN Guo-hua;WEI Dan;SHAO Wei;LI Li-juan;ZHANG Zhong-wen;YANG Jie;WU Xiao;CAI Wei-na;ZHOU Xiao-xiang;XIONG Jing;Department of Neurology,Integrated Traditional Chinese and Western Medicine Hospital of Wuhan;  
Objective:To observe effects of Xiaoyaosan on the memory ability and neurotransmitters expression in Alzheimer's disease(AD) mouce model with chronic mild stress. Methods: Fifty mice were randomly divided into five groups: blank group, D-Gal group, compound group, Xiaoyaosan group and Escitalopram group, with 10 mice in each group. The blank group was injected with normal saline, and the others were injected with D-gal for 42 days. From the twenty-ninth day, the mice in the Xiaoyaosan group were intragastrically administrated with Xiaoyaosan, and in the Escitalopram group with escitalopram. After the intragastric administration, the mice in both the Xiaoyaosan and Escitalopram groups were subjected to chronic stress for 6 hours each day, lasting for 14 days. Then Dark evading test and NE and 5-HT levels in all the mice were evaluated. Results: Compared to the groups of blank and D-gal, the escape latency time in the compound group was shortened and error times were increased in the Dark evading test, while the 5-HT and NA levels were decreased markedly. Compared to the compound group, the escape latency time in the Xiaoyaosan and Escitalopram groups were prolonged and error times were reduced, while 5-HT and NA were increased. Conclusion: Chronic mild stress and D-gal combination can be used to establish AD mouce model with stagnation of liver-QI. Xiaoyaosan can improve memory function and increase the serum 5-HT and NE levels in AD mice.
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