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Change of Complement C3 and C4 Levels in Dogs after Intracerebral Hemorrhage

TANG Xie-lin;YAO Qing-ning;XIA Xiang-guo;LI Qian-ke;LIU Sheng-hua;XIAO Kui;GU Ying-jiang;ZHONG Jun;ZHAO Chao;Department of Neurosurgery,Santai County People's Hospital;  
Objective:To study the correlation between perihematomal edema and levels of complements C3 and C4 in intracerebral hemorrhage(ICH) dogs. Methods: Thirty dogs were randomly divided into normal control group, imaging group and hematoma group equally. The normal control group had received no treatment whereas the ICH model was established in both the imaging and hematoma groups by stereotactic injection of autologous anti-coagulated blood into the brain. The peripheral blood C3 and C4 contents in the control and imaging groups were measured respectively at 6 h, 24 h, 72 h, 5 d, 7 d after surgery, while head CT scan was performed and the ratio of edema were calculated at each time point. Neurological deficits were evaluated by the Purdy PD standard. Results: In the ICH dogs, the C3 and C4 levels in peripheral blood and hematoma liquid began to increase 6 h after ICH and reached the peak at 72 h, then decreased. The C4 level at 6 h in the imaging and hematoma groups showed no significant difference compared to the control group(P0.05). However, at other time points investigated, the C3, C4 levels in the imaging and hematoma groups were significantly higher than those in the control group(P0.05). Purdy PD score began to decrease after ICH, and further decline at 72 h, then gradually return to baseline. Conclusion: The activation of complements C3 and C4 may be involved in the cerebral edema formation around hematoma and secondary brain damage after ICH.
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