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Effects of Chaihu-Shugan-San on Behavior and Neurogenesis of Hippocampal Dentate Gyrus in Epileptic Rats with Depression

YANG Ping;LI Liang;SUN Mei-zhen;Psychiatric Department, Brains Hospital of Hunan Province;  
Objective: To explore the effects of Chaihu-Shugan-San(CHSGS) on behavior and neurogenesis of the hippocampal dentate gyrus in chronic epileptic rats with depression. Methods: Twenty-four rats with depression which were selected from the chronic pilocarpine-induced epileptic rats were randomly divided into 3groups(8 in each): the groups of model, Fluoxetine and CHSGS treatment. And the normal control group was established(n=8). After 21 d of pilocarpine-induced epilepsy in rats, the model group received saline(10 mL/kg),the Fluoxetine group was given Fluoxetine(0.75 mg/kg), and the CHSGS group was given CHSGS(2.7 g/kg) for 1month. Saccharose water consumption test, open-field test and immunohistochemistry were used to observe the behavior and neurogenesis in the hippocampal dentate gyrus. Results: when compared with those in the normal control group, the consumption of saccharose water and behavioral scores were significantly decreased whereas the number of newborn neurons in the hippocampal dentate gyrus were increased in the other three groups(P0.05). The consumption of saccharose water, behavioral scores and numbers of newborn neurons in the hippocampal dentate gyrus were increased remarkably in the fluoxetine group and CHSGS group than than those in the model group(P0.05). There were no significant differences between the fluoxetine group and CHSGS group. Conclusion: CHSGS can increase the neurogenesis of the hippocampal dentate gyrus in epileptic rats with depression and effectively improve behavior recovery.
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