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COMT Val158Met Gene Polymorphisms and Schizophrenia Susceptibility: A Meta Analysis

XU Zhou-yang;LIU Xin;NO.2 Ward, Department of Psychiatry, Wuhan YouFu hospital;  
Background: To evaluate the correlation of COMT Val158 Met gene with susceptibility to schizophrenia. Methods: A meta-analysis was performed by searching the published literatures in PubMed, CNKI, CBM,EMBASE, MEDLINE and Wanfang databases. Overall and subgroup analyses were performed. Odds ratio(OR)and 95% confidence interval(CI) were used to evaluate the associations between COMT Val158 Met polymorphisms and schizophrenia risk. Statistical analysis was performed with Review Manager 5.1. Results:Seventeen studies addressing COMT Val158 Met polymorphisms were analyzed among a total of 4 935 schizophrenic cases and 4 282 controls. There was no evidence that the COMT Val158 Met polymorphism was associated with an increased schizophrenia risk(P0.05) in over all populations(heterozygote comparison, P=0.07, I2=1%; recessive model comparison, P=0.11, I2=0%). In subgroup analysis based on ethnic groups, no associations was found in Caucasus and Asians(P0.05). Conclusion: It is likely that the COMT Val158 Met gene polymorphism does not confer susceptibility to schizophrenia.
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