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《Neural Injury and Functional Reconstruction》 2014-06
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Establishment of Experimental Animal Model of Spinal Firearm Wounds under Conditions of High Temperature and High Humidity

GUO Ying;HUANG Zhi;LIU Lai-sheng;JIA Lian-shun;YUN Xiong;HUANG Jian-hou;Department of Orthopaedics, The PLA 187 Hospital;  
Objective: To establish the firearm injury model in the environment of high temperature and humidity and to study the pathological changes of the spinal cord after injury. Methods: Six healthy porcine were subjected to SCI models with high-energy gunshot in spinal cord of breast and lumbar section. The pathological changes of spinal cord were observed under optical microscopy(OM) immediately and six hours after surgery. Results: The general pathological changes were in agreement with high-energy ignition injury damage characteristics. Under OM, the blood vessels of spinal dura mater were dilated; subdural blood congestion were obvious, and neuronal cells in grey matter were degenerated, disappeared and dissolved; gray Nissl body mass were collpsed. Conclusion:The model was established with good stability and reproducibility.
【Fund】: 全军十一五指令性课题(No.08Z018)
【CateGory Index】: R826.5;R-332
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