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《Neural Injury and Functional Reconstruction》 2014-06
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Mitochondrial Division Inhibition Attenuates Aβ-induced Oxidative Stress Injury in Primary Microglial Cells

XIE Nan-chang;CHEN Chen;WANG Cui;ZHANG Qian;XIA Jian-hua;ZHANG Hong-wei;LIAN Ya-jun;Department of Neurology, the First Affiliated Hospital of Zhengzhou University;  
Objective: To investigate whether mitochondrial division inhibitor 1(mdivi-1) attenuates β-amyloid protein(Aβ)-induced oxidative stress injury in primary microglial cells. Methods: Primary microglial cells were randomly divided into control group, Aβ group, mdivi-1 group and Aβ+mdivi-1 group. The viability and apoptosis of cells, mitochondrial membrane potential, malondialdehyde(MDA) content, superoxide dismutase(SOD)content and 8-hydroxy-deoxyguanosine(8-OHd G) were examined. Results: Compared with control group, the cell viability of Aβ group was significantly reduced, the apoptotic cells was increased, the mitochondrial membrane potential and SOD activity were decreased, while the levels of MDA and 8-OHd G were increased(P0.05).Compared with the Aβ group, in the Aβ+mdivi-1 group, the cell viability was increased, the apoptotic cells was decreased, the mitochondrial membrane potential and SOD activity were increased, while the levels of MDA and 8-Ohd G were decreased(P0.05). Conclusion: Mdivi-1 exerts neuroprotective effects against Aβ-induced oxidative stress injury in primary microglial cells.
【Fund】: 国家自然科学基金(No.81201012 81371438)
【CateGory Index】: R741.02
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【Citations】
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1 XIE Nan-chang;CHEN Chen;WANG Cui;ZHANG Qian;ZHANG Hong-wei;XIA Jian-hua;LIAN Ya-jun;Department of Neurology,the First Affiliated Hospital of Zhengzhou University;;Inhibition of Mitochondrial Fission Attenuates Aβ-induced Microglia Apoptosis[J];Neural Injury and Functional Reconstruction;2014-05
2 ZHAO Yan-xin▲,LIU Xue-yuan,DONG Qiang,CUI Mei.▲Department of Neurology,Shanghai Tenth People's Hospital,Shanghai 20072,China;Roles of Microglia in the Specific Dopaminergic Neuronal Cell Death Induced by Paraquat[J];Neural Injury and Functional Reconstruction;2012-03
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