The Postoperative Iatrogenic Horner's Syndrome of Mongolian Gerbils after Cerebral Ischemia
WANG Na;LU Zu-neng;ZHANG Hong-yan;WANG Yun-fu;Department of Neurology,RenminHospital of Wuhan University;Department of Neurology,Taihe Hospital of Hubei University of Medicine;
Objective: To explore the pathogenesis of Horner's syndrome(HS) in Mongolian gerbils after cerebral ischemia. Methods: Forty gerbils were randomly divided into sham operation group and the groups ischemic operation 1, 2, and 3(n=10 respectively). Gerbils in the sham operation group were only treated with isolating carotid arteries, the ones in the ischemic operation group were treated with the bilateral common carotid artery occlusion surgery for 5 min. The incidence rates of HS, the NDS scores were compared at pre- and 1, 4, 7days post-operation. Pathological changes in the hippocampus, hypothalamus and brain stems were observed by HE staining at 7 days post-operation. Results: The incidence rate of HS in the sham operation group was 11.1%and37.5%, 44.4% and 60%. in the operation groups respectively NDS scores had no significant differences(P0.05) among the different groups at pre- and 1, 4, 7 days post- operation. In the operation group, HE staining showed obviously ischemic changes in hippocampus, ththe loss of cells was observed(P0.05). HE staining revealed no ischemic changes in the hypothalamus and brainstems in different groups. Conclusion: The results suggest that the high incidence rate of HS in the operation group was due to the mechanical damage during surgery instead of the complication of cerebral ischemia.