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Risk Factors of Cognitive Dysfunction in Patients with Primary Epilepsy

LIU Jian-guang;JIANG Hong-mei;WANG Zheng;LIU Zhong-zhi;LEI Jing-an;HAN Qi;ZHOU Yu-tao;GUO Xiao-hong;HE Xi-ju;Wuhan Third Hospital(Tongren Hospital of Wuhan University);Department of Gastroenterology,Dongfeng Hospital Affiliated to Hubei University of Medicine;Departmentof Neurology,Dongfeng Hospital Affiliated to Hubei University of Medicine;Hubei University of Medicine;  
Objective: To analyze the risk factors of cognitive dysfunction in patients with primary epilepsy.Methods: The cognitive dysfunction of one hundred cases with primary epilepsy(study group) and 50 healthy controls(control group) were evaluated by Wechsler Adult Intelligence Scale scale(WAIS- RC) cognitive function test. The related factors affecting the cognitive function were analyzed by single factor analysis and multiple linear stepwise regression analysis. Results: The scores of knowledge, comprehension, arithmetic and other 11 parameters scored in the cognitive function test of the study group were significantly lower than those in the control group(P0.001). Verbal IQ(VIQ) scores, performance IQ(PIQ) scores and full scale IQ(FIQ) in the study group were significantly lower than those in the control group(P0.001). Correlation analysis showed that FIQ and education, physical quantity, time of onset and seizure duration were significantly correlated with the injury(R=0.611). VIQ was significantly related to education and the number of anti-epileptic drugs(R=0.619). The PIQ was significantly related to time of onset, age, the number of antiepileptic drugs and education(R=0.571). Conclusion: The incidence of cognitive dysfunction in patients with primary epilepsy is significantly related to the degree of education, age, duration of disease, the number of antiepileptic drugs, and the duration of attacks.
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