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《Neural Injury and Functional Reconstruction》 2018-03
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Correlation between Atherosclerosis and Rupture of Intracranial Aneurysms

CHEN Xian-hai;XU Gao-feng;BAI Xiao-bin;XIE Wan-fu;Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiao Tong University;  
Objective: To investigate the correlation between atherosclerosis(AS) and intracranial aneurysm rupture. Methods: One hundred and twenty cases with intracranial aneurysm were included, which were divided into ruptured group(n=99) and unruptured group(n=21). Clinic data was collected and retrospectively analyzed. The related risk factors of intracranial aneurysms rupture were analyzed by χ2 test. The correlation between AS and intracranial aneurysm rupture was analyzed. Results: The gender, personal history of drinking and smoking, history of cardiovascular and cerebrovascular diseases, and the sites and the size of intracranial aneurysms were the risk factors for intracranial aneurysm rupture(P0.05). AS was more likely to be detected in intracranial aneurysm patients with arteriostenosis, early vascular endothelial injury and inflammatory response(P0.05). Multivariate logistic regression analysis results showed that AS was one of the main factors influencing the rupture of intracranial aneurysms. Conclusion: The gender, personal history of drinking and smoking,history of cardiovascular and cerebrovascular diseases, and the site and the size of intracranial aneurysms were the risk factors for intracranial aneurysm rupture. AS may be associated with intracranial aneurysm rupture.
【CateGory Index】: R54;R743
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