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《Foreign Medical Sciences Section On Neurology & Neurosurgery》 2005-04
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Anti-inflammatory effect of blocking ubiquitin-proteasome pathway in a rat model of focal cerebral ischemic and reperfusion injury

MAO Shi-Xian, YANG Qi-Dong, LI Zhen-Guo, HUANG Xiao-Song. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China  
Objective To investigate the neuroproctective mechanism of blocking ubiquitin-proteasome pathway (UPP). Methods Transient focal ischemic and reperfusion was produced by middle cerebral artery occlusion for 2 hrs in Sprague-Dawley rats. The UPP was blocked by clasto-lactacystin β-lactone. The infarction size was measured by TTC stain. Leukocyte infiltration was quantified by HE stain. Results Leukocyte infiltration and infarction size increased gradually after ischemic and reperfusion, peaking at 24 hrs. Blocking UPP reduced infarction and leukocyte infiltration. Infarction volume was reduced by 44% at 24 hrs. Conclusions Blocking UPP reduces leukocyte infiltration and produces neuroproctection through anti-inflammatory effects .
【CateGory Index】: R743
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