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《Journal of International Neurology and Neurosurgery》 2006-01
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Aquaporin-4 (AQP-4) expressions around hematoma in rats following intracerebral hemorrhage

LIU Jia, WANG Jian-Ping. Department of Neurology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, China  
Objective This paper aimed to explore the correlation of aquaporin-4 (AQP-4) expression with cerebral edema and injury, by studying the dynamic changes of AQP-4 expression around hematoma in rats following intracerebral hemorrhage (ICH) . Methods The experimental ICH model was established in SD rats by injecting the rats’ own artery blood into the caudate nucleus. Immunohistochemistry straining was used to detect the AQP-4 expression around hematoma at 6 and 12 hrs and 1, 3, 7 and 14 days after ICH. The brain water content was measured by the wet/dry weight method. Alexis method was used to examine the neurological deficit scores. Results The AQP-4 expression around hematoma increased at 12 hrs and reached a peak between 1-3 days after ICH. It remained higher than normal level at 7 days and returned to normal at 14 days basically following ICH. The brain water content increased from 6 hrs and peaked between 1-3 days following ICH. It was obviously reduced at 7 days and returned to normal at 14 days following ICH. The neurological deficit appeared from 6 hrs and the severest injury was observed between 12 h-3 d after ICH. The deficit was obviously assented at 7 days and recovered at 14 days after ICH. The expression level of AQP-4 around hematoma was positively correlated with the brain water content (x2_ mh=16.49, P0.05) and neurological deficit scores (x2_ mh=15.07, P0.05). Conclusions AQP-4 may play a role in the development of hemorrhagic cerebral edema and injury after ICH. The hemorrhagic cerebral edema and injury after ICH can be alleviated by inhibiting the AQP-4 expression.
【CateGory Index】: R743.34
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