Expression of NGF and BDNF in Astrocytoma
Wang Xiang-Peng, Yang Zhi-Yong, The Neurosurgery Department of the First Affiliated Hospital of Kunming Medical College, 650032Wang Ting-Hua. The Neuroscience Research Institut of Kunming Medical College 650031
Objective To examine the expression of Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) in astrocytoma, and to investigate the effects of NGF and BDNF on pathologic grading, region and tumorigenesis of astrocytoma. Methods NGF and BDNF expressions were detected using immunohistochemistry (S-P) in 70 cases of human astrocytoma and 5 cases of normal controls.Results The positive cell expressions rates of NGF and BDNF in varied pathologic grading astrocytoma were signinficantly different compared with that of the normal controls(P0.05). And also with signinficantly defference compared with that of the astrocytoma which located in different regions(P0.05).Conclusions This expression of NGF and BDNF was increased in astrocytoma and were related to the pathologic grading and region of astrocytoma .NGF and BDNF may participate in the tumorigenesis of astrocytoma.