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Serum interleukin-6 level in patients with poststroke depression

TONG Lin, LI Zuo-Xiao. Department of Critical Care Medicine, Affiliated Hospital, Guangdong Medical College, Zhanjiang, Guangdong 524001, China  
Objective To study the changes of serum interleukin-6 (IL-6) level in patients with poststroke depression (PSD) and investigate the relationship of serum IL-6 with depression. Methods Fifty-nine patients with PSD, 36 with non-PSD and 43 normal controls were enrolled in this study. The 59 patients with PSD were randomly administered with anti-depressant therapy+conventional therapy (n=29) or with routine therapy alone (n=30). Serum IL-6 levels were measured using radioimmunoassay. The degree of depression was evaluated by the Hamilton rating scale for depression (HAMD). Results Before treatment, serum IL-6 levels in PSD group were significantly higher than in the non-PSD and normal control group (P0.01). After treatment, both the score of HAMD (P0.01) and the level of IL-6 (P0.01) in anti-depressant therapy (ADT) group were significantly lower than those in the conventional therapy group. There were significantly positive correlation in the serum IL-6 levels and the HAMD score in the PSD group before treatment (r=0.375, P0.01), and in the ADT group (r=0.452, P0.01) and conventional therapy group (r=0.397, P0.01) after treatment. Conclusions Serum IL-6 levels increase significantly in patients with PSD and are associated with the degree of depression.
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