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Effects of ethanol extracts of Caesalpinia Sappan L on IFN-γ in myasthenia gravis

LI Xin-Jun, GAO Li, XIONG Yue-Jun. Department of Neurosurgery, The Fouth People,s Hospital of Zigong, Zigong, Sichuan 643000, China  
Objective This study examined the changes of acetylcholine receptor antibody (AChRab) and γ-interferon (IFN-γ) in patients with myasthenia gravis treated with ethanol extracts of Caesalpinia Sappan L, in order to explore possible immunological mechanisms of ethanol extracts of Caesalpinia Sappan L for the treatment of myasthenia gravis. Methods Blood levels of AchRab and IFN-γ were measured using enzyme-linked immunosorbentassay (ELISA) in 69 patients with myasthenia gravis, including an ethanol extracts of Caesalpinia Sappan L therapy group (n=34) and a conventional therapy group (n=35) and in 30 normal control. Results Blood levels of AchRab and IFN-γ in the ethanol extracts of Caesalpinia Sappan L therapy and conventional therapy groups were significantly higher than in the normal control group (P0.05) before and after treatment. There were no significant differences in the blood levels of AchRab and IFN-γ between the two therapy groups before treatment, but after treatment the blood levels of AchRab and IFN-γ in the ethanol extracts of Caesalpinia Sappan L therapy group were significantly lower than those in the conventional therapy group (P0.05). Conclusions Ethanol extracts of Caesalpinia Sappan L relieve amyasthenia possibly through reducetion of blood levels of IFN-γ and AchRAb in patients with myasthenia gravis.
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