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Study on LRP(TTTC)n Gene Polymorphism in Chinese Type Ⅱb Hyperlipoproteinemia

YIZirong ,ZHOUXin ,ZHAOYuanhua,etal.  
Objective Tostudy LRP(TTTC)n geno type and itsrelation ship with serumlipids,lipoproteinsandapolipoproteinsinChinesepatientswithtypeⅡbhyperlipoproteinemia .Methods LRP (TTTC)ngenotypewereanalysedbypolymerasechainreatients(PCR)andhighvoltagepolyacryamiedgelelectrophesis.Thegelswerestainedbysilvernitrate.Serumlipidwerebyenztmemothodandapolipoprteinsweremeasuredbyradialimmunodiffusionin 10 1healthycontroland 72typeⅡbhyperlipoproteinemiapatients.Result ComparedwiththecontrolgroupthevaluesofserumTG、TCH、LDL C、ApoBinpatientswithtypeⅡbhyperlipoproteinemiawresignifi canylyincreased(P 0 0 1) .WithachangeoftypeⅡbhyperlipoproteinemiafrom 5 / 5and 5 / 6to 6 / 6 ,theconcentrationsofTC、LDL CandApoBtendeddownwardsgraduallyandhadstatisticallySignification .HoweverthehealthygroupalsohadsuchatendencybutdonotStatisticallysignificantion .Conclusion LRP(TTTC)ngenetypewasassociatedwithserumlipidlevelintypeⅡbhyperlipoproteinemia .
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