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《International Journal of Laboratory Medicine》 2008-02
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The clinical significance of serum soluble intercellular adhesion molecule-1 and P-selectin in hepatocellular carcinoma

GAO She-jun~1,GUO Ming-wei~1,HU Yi-jiang~1,et al.1.Department of Clinical Laboratory, the Fourth Hospital of Hebei Medical University,Shijiazhuan 050011,China;2.Shake Municipal Hospital of Hehei Province,Shahe 054100,China  
Objective To investigate the serum expression levels of soluble intercellular adhesion molecule-1(sICAM 1)and P-selectin,and to explore the relationship between the two indices and recurrence as well as metastasis of hepatocellular carcinoma(HCC).Methods ABC-ELISA was applied to detecting the levels of sICAM-1 and P selectin in serum of 78 patients with HCC before and after therapy(day 30 after treatment),meanwhile,alpha fetoprotein(AFP)concentration was measured. SPSS10.0 software and receiver operating characteristic(ROC)curve were adopted to analyze the differences of the above indices,and evaluate their clinical value.Results The levels of sICAM-1 and P selectin of patients with HCC were significantly higher than those of normal control group(P0.01),and kept increasing with TNM staging.The levels of peripheral blood sICAM-1 and P-selectin decreased markedly in effective group,while in ineffective group,their levels were elevated.After therapy,the levels of serum sICAM-1 and P-selectin were both higher in recurrence group and metastasis group than those of non recurrence group and non-metastasis group.Correlation analysis showed there were positive correlation between slCAM-1 as well as P-selectin and AFP(r=0.874,P0.05;r =0.892,P0.01 reapectively).ROC curve analysis showed the diagnostic efficacy of sICAM-1 was optimal,followed by AFP and P-selectin.Conclusion sICAM-1 and P-selectin correlates closely with development,recurrence or metastasis of hepatocellular carcinoma(HCC).Serum slCAM-1 and P-selectin may be used as important biological parameters infelecting recurrence or metastasis trend of HCC,contributing to auxiliary diagnosis,surveillance of progression of disease and observation of therapeutic effects and they are maybe potential predictors of metastatic recurrence in HCC.
【Fund】: 河北省卫生厅科技攻关课题(2003098)
【CateGory Index】: R735.7
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